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Historical Comparison: Previous Obesity Drug Timelines Why retatrutide might be faster: Eli Lilly has recent tirzepatide approval experience and knows FDA expectations for GLP-1-class drugs

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Patients experiencing intolerable symptoms may benefit from slower titration or temporarily maintaining a lower dose before advancing

In REDEFINE 1, GI events were reported in 79.6% of CagriSema participants versus 39.9% on placebo, including nausea (55%), constipation (30.7%), and vomiting (26.1%)